Nokea
Disinfection with chemicals acting on cell surface:
- A. Soaps
- B. Phenols
- C. Amines
- D. Polymyxin
Correct Answer: B
Rationale: The correct answer is B: Phenols. Phenols act on the cell surface by disrupting cell membranes and denaturing proteins, leading to cell death. Soaps (A) work by lifting dirt and microbes off surfaces, not directly acting on cell surfaces. Amines (C) are typically used as disinfectants targeting specific enzymes in microbes, not cell surfaces. Polymyxin (D) is an antibiotic that works by disrupting cell membranes internally, not on the cell surface.
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The six generally recognized types of H. Influenzae are: a,b,c,d,e and f. They are divided on the basis of their:
- A. Vi-antigen
- B. K-antigen
- C. O-antigen
- D. H-antigen
Correct Answer: B
Rationale: The correct answer is B: K-antigen. H. Influenzae types are classified based on their capsular polysaccharides, which are known as K-antigens. The K-antigen is a major virulence factor and plays a crucial role in the pathogenicity of H. Influenzae. The other options (A, C, D) are not used to classify H. Influenzae types. Vi-antigen is related to Salmonella serotyping, O-antigen is characteristic of gram-negative bacteria such as Escherichia coli and Salmonella, and H-antigen is typically associated with flagellar antigens of bacteria like Salmonella and E. coli.
Which one is not true for the adaptive immunity:
- A. Is mainly observed in the skin and mucous membranes
- B. Develops immune memory
- C. Has a specificity
- D. Evolutionary newer in comparison to the innate immunity
Correct Answer: A
Rationale: The correct answer is A because adaptive immunity is not mainly observed in the skin and mucous membranes. Adaptive immunity is a systemic response that involves specific immune cells and antibodies targeting specific pathogens. It develops immune memory (B), meaning it can recognize and respond faster upon re-exposure to the same pathogen. Adaptive immunity also has specificity (C), as it can target specific antigens. Lastly, adaptive immunity is not evolutionarily newer in comparison to innate immunity (D), as both systems have co-evolved to provide comprehensive protection against pathogens.
A patient with a productive cough and fever had a sputum smear revealing Gram-positive cocci in clusters. What is the most likely causative agent?
- A. Staphylococcus aureus
- B. Streptococcus pneumoniae
- C. Neisseria meningitidis
- D. Klebsiella pneumoniae
Correct Answer: A
Rationale: The correct answer is A: Staphylococcus aureus. Staphylococcus aureus is a Gram-positive cocci bacterium that forms clusters and commonly causes pneumonia with a productive cough and fever. It is frequently found in sputum smears in such cases. Streptococcus pneumoniae (B) is another common cause of pneumonia but typically appears in pairs or chains, not clusters. Neisseria meningitidis (C) is a Gram-negative diplococcus that causes meningitis, not pneumonia. Klebsiella pneumoniae (D) is a Gram-negative bacterium that can cause pneumonia but appears as Gram-negative rods, not Gram-positive cocci in clusters.
Which of the following transport mechanisms transports water across the plasma membrane?
- A. osmosis
- B. facilitated diffusion
- C. phagocytosis
- D. exocytosis
Correct Answer: A
Rationale: Osmosis is the correct answer because it is the process by which water molecules move across a semi-permeable membrane from an area of low solute concentration to an area of high solute concentration. This movement occurs passively, driven by the concentration gradient. Facilitated diffusion (B) involves the transport of specific molecules with the help of carrier proteins, not water. Phagocytosis (C) is a process where cells engulf solid particles, not water molecules. Exocytosis (D) is the process of releasing substances from a cell by fusion of vesicles with the cell membrane, not the transport of water across the membrane.
A 60-year-old patient was hospitalized to the surgical department because of infection caused by blue pus bacillus (Pseudomonas aeruginosa) which is sensative to penicillin antibiotics. Indicate which of the given penicillins has marked activity to the Pseudomonas aeruginosa?
- A. Carbenicillin disodium
- B. Benzylpenicillin
- C. Methicillin
- D. Oxacillin
Correct Answer: A
Rationale: The correct answer is A: Carbenicillin disodium. Carbenicillin is a semisynthetic penicillin that has marked activity against Pseudomonas aeruginosa. This is due to its extended spectrum of activity and increased stability against beta-lactamases produced by Pseudomonas aeruginosa. Carbenicillin is commonly used to treat infections caused by this bacterium.
Choice B: Benzylpenicillin (Penicillin G) has limited activity against Pseudomonas aeruginosa.
Choice C: Methicillin is not effective against Pseudomonas aeruginosa.
Choice D: Oxacillin also has limited activity against Pseudomonas aeruginosa.
In summary, Carbenicillin is the correct choice due to its marked activity against Pseudomonas aeruginosa compared to the other penicillins listed.