Disorders of the Genitourinary System Related

Review Disorders of the Genitourinary System related questions and content

Due to its potential for severe hepatotoxicity, Nevirapine should NOT be initiated in:

  • A. Women with CD4 cell counts >150 cells/mm3 or in men with CD4 cell count >400 cells/mm3
  • B. Women with CD4 cell counts >250 cells/mm3 or in men with CD4 cell count >400 cells/mm3
  • C. Women with CD4 cell counts >250 cells/mm3 or in men with CD4 cell count >500 cells/mm3
  • D. Women with CD4 cell counts >250 cells/mm3 or in men with CD4 cell count >450 cells/mm3
Correct Answer: B

Rationale: The correct answer is B. Nevirapine has a higher risk of severe hepatotoxicity in patients with higher CD4 cell counts. Choice B specifies a lower threshold for CD4 cell counts in women compared to men, which aligns with the caution needed for initiating Nevirapine. Choices A, C, and D have higher CD4 cell count thresholds for both women and men, which would increase the risk of hepatotoxicity if Nevirapine is initiated in those patients. Therefore, Choice B is the most appropriate option to minimize the risk of hepatotoxicity when initiating Nevirapine.