Nokea
Elimination after 4 half lives in first order kinetics is
- A. 84%
- B. 93%
- C. 80.50%
- D. 4.75%
Correct Answer: B
Rationale: After 4 half-lives, 93.75% (1 - 1/16) of the drug is eliminated in first-order kinetics.
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Drugs mostly cross biological membranes by
- A. Passive diffusion
- B. Active diffusion
- C. Active transport
- D. Carrier mediated transport
Correct Answer: A
Rationale: Most drugs cross membranes via passive diffusion based on concentration gradients.
The patient is taking a drug that affects the body by increasing cellular activity. Where does this drug work on the cell?
- A. Receptor sites
- B. Cell membrane
- C. Golgi body
- D. Endoplasmic reticulum
Correct Answer: A
Rationale: Many drugs are thought to act at specific areas on cell membranes called receptor sites. After the receptor site is activated, this in turn activates the enzyme systems to produce certain effects, such as increased or decreased cellular activity, changes in cell membrane permeability, or alterations in cellular metabolism. Receptor sites are generally located on the outside of cells and allow the drug to bypass the cell membrane. The Golgi body and endoplasmic reticulum are not involved in this process.
Which of the following is a side effect of propylthiouracil?
- A. Agranulocytosis
- B. Arrhythmias
- C. Diabetes
- D. Hypertension
Correct Answer: A
Rationale: Propylthiouracil can cause agranulocytosis, a severe reduction in white blood cells, as a serious side effect.
Which of the following is an II generation sulfonylurea drugs, which are used for the treatment of diabetes mellitus type II:
- A. Chlorpropamide
- B. Tolazamide
- C. Tobutamide
- D. Glipizide
Correct Answer: D
Rationale: Glipizide is a second-generation sulfonylurea, more potent and with fewer side effects than first-generation drugs like chlorpropamide.
Abrupt withdrawal of beta blockers can be life threatening. Patients at highest risk for serious consequences of rapid withdrawal are those with:
- A. Angina
- B. Coronary artery disease
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: C
Rationale: Patients with angina and CAD are at high risk for rebound effects like myocardial infarction.