Nokea
Food can alter the pH of the stomach, leading to:
- A. Enhanced drug metabolism
- B. Altered vitamin K absorption
- C. Increased vitamin D absorption
- D. Altered drug bioavailability
Correct Answer: D
Rationale: Changes in stomach pH due to food can affect drug dissolution and absorption, altering bioavailability.
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Which drug reference contains monographs about virtually every single-entity drug available in the United States and describes therapeutic uses of drugs, including approved and unapproved uses?
- A. Martindale: The Complete Drug Reference
- B. AHFS Drug Information
- C. Drug Reference
- D. Drug Facts and Comparisons
Correct Answer: B
Rationale: AHFS Drug Information contains monographs about virtually every single-entity drug available in the United States and describes therapeutic uses of drugs, including approved and unapproved uses.
A 27-year-old man is admitted to the emergency department (ED) after a serious motorcycle accident. The patient has a head injury, abrasions covering the left side of his body, a broken left femur, and internal injuries that are not fully assessed at this time. He is transferred from the ED to the intensive care unit (ICU). The nurse who is going to care for this patient in the ICU knows that a priority responsibility in regard to drug therapy is what?
- A. Support vital functions
- B. Continue curative treatment
- C. Institute life-saving treatment
- D. Monitor patient's response
Correct Answer: D
Rationale: Monitoring response ensures therapy adjusts to the patient's critical condition, a priority in ICU.
All the following cross placenta except
- A. Warfarin
- B. Heparin
- C. Phenindione
- D. Morphine
Correct Answer: B
Rationale: Heparin, a large molecule, does not cross the placenta; others do.
Thirty-two units of Humulin insulin is ordered for the patient. The insulin is supplied in a multidose vial that is labeled 100 units/mL. How much insulin would be needed to treat this patient?
- A. 0.032 cc
- B. 0.32 cc
- C. 3.2 cc
- D. 32 cc
Correct Answer: B
Rationale: A cc is equivalent to an mL. There are 100 units in each cc. Divide that amount by 32 units for the answer (0.32 cc).
An Investigational New Drug is filed with the U.S. Food and Drug Administration:
- A. When the manufacturer has completed phase III trials
- B. When a new drug is discovered
- C. Prior to animal testing of any new drug entity
- D. Prior to human testing of any new drug entity
Correct Answer: D
Rationale: An IND is filed before human testing , after preclinical (animal) studies, to ensure safety before clinical trials begin.