Nokea
Glibenclamide and chlorpropamide:
- A. Are well absorbed in Gl tract
- B. Increase release of endogenic insulin by pancreatic beta cells
- C. Is used as hormone replacement therapy for diabetes mellitus
- D. Is for internal use only
Correct Answer: B
Rationale: Glibenclamide and chlorpropamide increase endogenous insulin release from beta cells.
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The antidote for paracetamol poisoning is:
- A. Acetylsalicylic acid
- B. Acetylcysteine
- C. Prostacyclin
- D. Omeprazole
Correct Answer: B
Rationale: Acetylcysteine replenishes glutathione, detoxifying paracetamol's toxic metabolite.
Patient education when prescribing clopidogrel includes:
- A. Do not take any herbal products without discussing it with the provider
- B. Monitor urine output closely and contact the provider if it decreases
- C. Clopidogrel can be constipating, use a stool softener if needed
- D. The patient will need regular anticoagulant studies while on clopidogrel
Correct Answer: A
Rationale: Herbal products can increase bleeding risk with clopidogrel; urine or constipation aren't typical issues, and INR isn't monitored.
Data in the electronic health record that the provider reviews prior to a patient encounter varies with the clinic setting. In an urgent care clinic, the provider should review:
- A. The patient's current diagnosis and history
- B. Drugs the patient is currently taking
- C. Any recent previous encounter for the same problem as this visit and what was done
- D. All of the above
Correct Answer: D
Rationale: In urgent care, reviewing diagnosis, medications, and prior encounters ensures comprehensive care.
Fasting for an extended period can:
- A. Increase drug absorption due to lack of competition between food and the drug
- B. Alter the pH of the gastrointestinal tract, affecting absorption
- C. Cause vasoconstriction, leading to decreased drug absorption
- D. Shrink the stomach, causing decreased surface area for drug absorption
Correct Answer: A
Rationale: Fasting increases absorption of some drugs by eliminating food-related delays in gastric emptying and competition for absorption.
Metformin is a primary choice of drug to treat hyperglycemia in type 2 diabetes because it:
- A. Substitutes for insulin usually secreted by the pancreas
- B. Decreases glycogenolysis by the liver
- C. Increases the release of insulin from beta cells
- D. Decreases peripheral glucose utilization
Correct Answer: B
Rationale: Metformin reduces hepatic glucose output (glycogenolysis), key in type 2 diabetes; it doesn't mimic insulin or increase release .