Wongs Essentials of Pediatric Nursing 11th Edition Test Bank Related

Review Wongs Essentials of Pediatric Nursing 11th Edition Test Bank related questions and content

In children diagnosed with sickle cell disease (SCD), tissue damage results from which of the following?

  • A. Air hunger and respiratory alkalosis due to deoxygenated red blood cells.
  • B. Hypersensitivity of the central nervous system (CNS) due to elevated serum bilirubin levels
  • C. A general inflammatory response due to an autoimmune reaction from hypoxia
  • D. Local tissue damage with ischemia and necrosis due to obstructed circulation
Correct Answer: D

Rationale: In children diagnosed with sickle cell disease (SCD), tissue damage results from local tissue damage with ischemia and necrosis due to obstructed circulation. Sickle cell disease is a genetic disorder characterized by abnormal hemoglobin that causes red blood cells to assume a sickle shape. These sickle-shaped cells can adhere to blood vessel walls, leading to vaso-occlusion and impaired blood flow. This obstruction results in tissue ischemia and eventual necrosis, causing significant pain and organ damage. The chronic vaso-occlusive events in SCD are responsible for the development of acute and chronic complications seen in affected individuals, such as painful crises, stroke, and organ damage.