Nokea
In the presence of naloxone, a higher concentration of morphine is required to elicit full pain relief. Naloxone by it self has no effect. Which of the following is correct regarding these medications?
- A. Naloxone is a competitive antagonist
- B. Morphine is a full agonist, and naloxone is a partial agonist
- C. Morphine is less efficacious than is naloxone
- D. Morphine is less potent than is naloxone
Correct Answer: A
Rationale: Naloxone shifts morphine's dose-response curve rightward (increased EC50), typical of competitive antagonism, with no intrinsic effect.
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The MMR vaccine is not recommended for pregnant women because:
- A. Pregnant women do not build adequate immunity to the vaccine
- B. There is a risk of the pregnant women developing measles encephalopathy
- C. There is a risk of the fetus developing congenital rubella syndrome
- D. Pregnant women can receive the MMR vaccine
Correct Answer: C
Rationale: MMR (live vaccine) risks fetal congenital rubella syndrome ; pregnancy contraindicates it, not immunity or encephalopathy .
When reviewing information about the Orphan Drug Program, which of the following would the nurse expect to find? (Select one that does not apply.)
- A. The program encourages the development and marketing of products to treat rare diseases.
- B. The program grants provisional approval with a written commitment from the drug company to formally demonstrate client benefits.
- C. The program provides for incentives, such as research grants, protocol assistance, and special tax credits, to develop products to treat rare diseases.
- D. The program grants 7 years of exclusive marketing rights to the manufacturer if approved.
Correct Answer: B
Rationale: The Orphan Drug Program encourages the development and marketing of products used to treat rare diseases. The program provides incentives to encourage manufacturers to develop orphan drugs, and if approved, the manufacturer has 7 years of exclusive marketing rights. Accelerated programs involve provisional approval and approval based on preliminary evidence.
Decongestants such as pseudoephedrine (Sudafed):
- A. Are Schedule III drugs in all states
- B. Should not be prescribed or recommended for children under 4 years of age
- C. Are effective in treating the congestion children experience with the common cold
- D. May cause drowsiness in patients of all ages
Correct Answer: B
Rationale: Pseudoephedrine is unsafe for children under 4 due to serious side effects; it's not Schedule III , variably effective in kids , or typically sedating .
Which of the following drug shows foetal hydantoin syndrome?
- A. Alcohol
- B. Phenytoin
- C. Ethosuximide
- D. Phenobarbitone
Correct Answer: B
Rationale: Phenytoin is associated with fetal hydantoin syndrome, characterized by craniofacial abnormalities and growth deficits, due to its teratogenic effects during pregnancy.
What is the mechanism of action of miglitol?
- A. Decreased glucagon release
- B. Increased insulin release
- C. Increased insulin sensitivity in peripheral tissues
- D. Inhibits intestinal brush border enzymes
Correct Answer: D
Rationale: Miglitol inhibits intestinal brush border enzymes, slowing carbohydrate digestion and absorption.