Nokea
Isoniazid (INH) may induce a deficiency of which vitamin?
- A. B6
- B. C
- C. D
- D. E
Correct Answer: A
Rationale: Isoniazid interferes with vitamin B6 (pyridoxine) metabolism, increasing deficiency risk.
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The nurse is caring for a patient who is chronically irritable and anxious and prone to violent behaviors. The patient has several teeth missing and has dental caries in the remaining teeth. The nurse suspects previous chronic use of which drug?
- A. Alcohol
- B. Cocaine
- C. LSD
- D. Methamphetamine
Correct Answer: D
Rationale: Methamphetamine causes tooth decay ('meth mouth') and agitation; cocaine less so. Patients previously exposed to methamphetamine use will exhibit these symptoms, and the physical effects of extended methamphetamine use are notable tooth decay and dermatologic deterioration.
A 12-month-old child just received the first measles, mumps, and rubella (MMR) vaccine. For which of the following possible reactions to this vaccine should the nurse teach the parents to monitor? (Select all that apply.)
- A. Bleeding
- B. Swollen glands
- C. Bruising
- D. Headache
Correct Answer: B
Rationale: Rash and swollen glands are common MMR reactions; bruising and headache are less typical.
A drug with a half-life of 4 hours is administered at a dosage of 100 mg. How much of the drug will be in the patient's system 8 hours after administration?
- A. 75 mg
- B. 50 mg
- C. 37.5 mg
- D. 25 mg
Correct Answer: D
Rationale: The half-life of a drug is the time it takes for the amount of drug in the body to decrease to 1 half the peak level it previously achieved. Option A would occur 2 hours after administration of the drug. Option B would occur at 4 hours. Option C would occur at 6 hours. Option D would occur at 8 hours after the original administration of the drug.
Vincristine toxicity frequently presents as:
- A. Anemia
- B. Neutropenia
- C. Thrombocytopenia
- D. Polyneuritis
Correct Answer: D
Rationale: Vincristine commonly causes neurotoxicity, including polyneuritis.
A 75-year-old woman with diabetes is taking an oral antidiabetic drug. One day she goes without eating for 18 \mathrm{~h}. Her serum glucose concentration is 48 \mathrm{mg} / \mathrm{dL} (hypoglycemic) upon arrival at the emergency department, where she is deemed to be in critical condition. Which of the following drugs most likely aggravated this fasting hypoglycemia?
- A. Acarbose
- B. Glyburide
- C. Metformin
- D. Pioglitazone
Correct Answer: B
Rationale: Glyburide, a sulfonylurea, can cause severe hypoglycemia, especially during fasting, due to prolonged insulin release.