Nokea
Multi-photon microscopy has proved to be an invaluable tool for the evaluation of the dynamics of immune responses in vivo. The following is a list of observations derived from intra-vital microscopy. Identify the incorrect statement.
Correct Answer: D
Rationale: The correct answer is D because dendritic cells do not typically move rapidly through the germinal center during an immune response. Dendritic cells usually interact with T cells in the paracortex to present antigens, and they are not known to migrate rapidly through the germinal center.
A: This statement is correct as T cells do make stable and prolonged contacts with APCs in the paracortex during immune responses.
B: This statement is incorrect as B cells do not move at the same speed and randomly in follicles in the absence of antigens. They respond to signals and cues in the microenvironment.
C: This statement is correct as specific B cells can quickly direct themselves towards the source of antigen during an infection.
In summary, choice D is incorrect because dendritic cells do not move rapidly through the germinal center during an immune response, while the other choices accurately describe behaviors of immune cells during immune responses.