Nokea
Pharmacoeconomics is:
- A. The study of the part of the U.S. economy
- B. The study of the impact of prescription drug costs on the overall economy
- C. The analysis of the costs and consequences of any health-care-related treatment or service
- D. The analysis of the clinical efficacy of the drug
Correct Answer: C
Rationale: Pharmacoeconomics evaluates costs and outcomes of health-care interventions.
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The following are recognized effects of propranolol except
- A. Increases microcoronary blood flow
- B. Decrease in heart rate
- C. Decrease in cardiac output
- D. Reduction in ventricular systolic pressure
Correct Answer: A
Rationale: Propranolol reduces coronary flow; other effects are correct.
Angina is caused by:
- A. Blocking beta1 receptors with a constant binding of noradrenaline
- B. Activating beta2 receptors
- C. Beta1 receptors are not active anymore
- D. Extreme binding of noradrenaline due to up regulation
Correct Answer: D
Rationale: Angina results from myocardial ischemia, often due to excessive demand or reduced supply, which can be exacerbated by upregulated noradrenaline binding increasing heart workload.
AH are prodrugs except
- A. Enalapril
- B. Paracetamol
- C. Sulphamethoxazole
- D. Trimethoprim
Correct Answer: D
Rationale: Enalapril is a prodrug; paracetamol, sulphamethoxazole, and trimethoprim are active drugs.
Traditional Chinese medicine utilizes yin (cooling) versus yang (warming) in assessing and treating disease. Menopause is considered a time of imbalance, therefore the Chinese herbalist would prescribe:
- A. Herbs which are yang in nature
- B. Herbs that are yin in nature
- C. Ginger
- D. Golden seal
Correct Answer: B
Rationale: Menopause is a yin-deficient state (hot flashes), so yin (cooling) herbs are prescribed.
The patient tells the nurse about a new drug being tested to treat the disease she was diagnosed with and asks the nurse whether the doctor can prescribe a medication still in the preclinical phase of testing. What is the nurse's best response?
- A. The doctor would have to complete a great deal of paperwork to get approval to prescribe that drug.
- B. Sometimes pharmaceutical companies are looking for volunteers to test a new drug and the doctor could give them your name.
- C. Drugs in the preclinical phase of testing are only tested on animals and so would not be available to you.
- D. Drugs in the preclinical phase of testing are given only to healthy young men and so would not be available to you.
Correct Answer: C
Rationale: During the preclinical phase of testing drugs are tested on animals and are not available to patients. In phase I, the drug is tested on volunteers who are usually healthy young men. It is only in phase III studies that the drug is made available to prescribers who agree to closely monitor patients getting the medication.