Nokea
Phase IV clinical trials in the United States are also known as:
- A. Human bioavailability trials
- B. Post marketing research
- C. Human safety and efficacy studies
- D. The last stage of animal trials before the human trials begin
Correct Answer: B
Rationale: Phase IV is post-marketing research , monitoring drugs after approval, unlike earlier phases or animal studies.
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Which online drug reference makes available to healthcare providers and the public a standard, comprehensive, up-to-date look up and downloadable resource about medicines?
- A. American Drug Index
- B. American Hospital Formulary
- C. DailyMed
- D. Drug Reference
Correct Answer: C
Rationale: DailyMed makes available to healthcare providers and the public a standard, comprehensive, up-to-date look up and downloadable resource about medicines. The American Drug Index, American Hospital Formulary, and Drug Reference are not designed for public use in this manner.
Plasma concentration of drug at time 0 is 96(g/ml). If t½ is 2 hours concentration in plasma at 10 hours will be
- A. 48
- B. 24
- C. 12
- D. 3
Correct Answer: D
Rationale: In first-order kinetics, the concentration halves every half-life (t½ = 2 hours). At 10 hours (5 half-lives), 96 → 48 → 24 → 12 → 6 → 3 µg/ml.
When administering parenteral drugs, which of the following routes would the nurse use? (Select one that does not apply.)
- A. Subcutaneous
- B. Intramuscular
- C. Intradural
- D. Intravenous
Correct Answer: C
Rationale: A nurse can administer parenteral drugs via subcutaneous, intramuscular, intravenous, intradermal, and, in some instances, intra-arterial routes by means of a catheter placed by a physician in an artery. The primary health care provider can administer a drug via the intradural route.
Genetic testing for VCORC1 mutation to assess potential warfarin resistance is required prior to prescribing warfarin.
- A. TRUE
- B. FALSE
Correct Answer: B
Rationale: VCORC1 testing is recommended but not required before prescribing warfarin; it's optional to guide dosing.
In the blood glucocorticoids cause:
- A. Increase amount of eosinophles
- B. Lymphocytosis
- C. Increase amount of neutrophils
- D. Increase amount of basophiles
Correct Answer: C
Rationale: Glucocorticoids increase neutrophils while decreasing eosinophils and lymphocytes in the blood.