Nokea
Regarding bilirubin:
- A. unconjugated bilirubin is more soluble than conjugated
- B. all conjugated bilirubin is excreted via the intestine
- C. bile duct obstruction causes jaundice secondary to unconjugated hyperbilirubinaemia
- D. haemolytic anaemia may cause ?????? hyperbilirubinaemia
Correct Answer: D
Rationale: Correct Answer: D
Rationale:
1. Hemolytic anemia results in increased breakdown of red blood cells.
2. Bilirubin is produced during the breakdown of heme in red blood cells.
3. Increased breakdown leads to elevated unconjugated (indirect) bilirubin levels.
4. This unconjugated bilirubin can overwhelm the liver's conjugation capacity, causing hyperbilirubinemia.
Summary:
A: Incorrect. Conjugated bilirubin is more soluble than unconjugated.
B: Incorrect. Conjugated bilirubin is excreted via urine, not intestine.
C: Incorrect. Bile duct obstruction causes conjugated hyperbilirubinemia, not unconjugated.
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The posterior pituitary stores and releases:
- A. Growth hormone & Prolactin
- B. Prolactin & Oxytocin
- C. Oxytocin & ADH
- D. ADH & GH
Correct Answer: C
Rationale: The correct answer is C: Oxytocin & ADH. The posterior pituitary stores and releases hormones produced by the hypothalamus. Oxytocin is responsible for uterine contractions during childbirth and milk ejection during breastfeeding. ADH (anti-diuretic hormone) regulates water balance by influencing the reabsorption of water by the kidneys. Growth hormone (GH) and Prolactin are released by the anterior pituitary, not the posterior pituitary. Therefore, choices A, B, and D are incorrect as they do not represent the hormones stored and released by the posterior pituitary.
The 'hormone response element' is located on the cell __________.
- A. membrane
- B. DNA
- C. RNA
- D. enzymes
Correct Answer: B
Rationale: The correct answer is B: DNA. Hormone response elements are specific DNA sequences where hormone receptors bind to regulate gene expression. This binding initiates the transcription of target genes. Choices A, C, and D are incorrect because hormone response elements are not located on the cell membrane, RNA, or enzymes. The key is understanding that hormone receptors act on DNA to regulate gene expression, making choice B the most appropriate answer.
The clusters of cells in the pancreas that produce hormones are the .
- A. islets of Langerhans
- B. pancreatic medulla
- C. pancreatic cortex
- D. nodules
Correct Answer: A
Rationale: The correct answer is A: islets of Langerhans. These clusters of cells in the pancreas are responsible for producing hormones such as insulin and glucagon. They play a crucial role in regulating blood sugar levels. The other choices, B: pancreatic medulla, C: pancreatic cortex, and D: nodules, are incorrect as they do not accurately describe the specific clusters of cells in the pancreas responsible for hormone production. It is important to understand the function and location of the islets of Langerhans to grasp the endocrine role of the pancreas.
Regarding parasympatholytics, the following statement is WRONG:
- A. Hyoscine is preferred over atropine in preanesthetic medication of thyrotoxic patients.
- B. Pirenzepine is preferred over propantheline in the treatment of intestinal colic.
- C. Ipratropium is better than atropine in the treatment of bronchial asthma
- D. Tropicamide is better than atropine in fundus examination
Correct Answer: B
Rationale: The correct answer is B. Pirenzepine is NOT preferred over propantheline in the treatment of intestinal colic because pirenzepine is a selective M1 receptor antagonist used for peptic ulcer disease, while propantheline is an anticholinergic used for GI spasms. Choice A is incorrect because atropine is preferred over hyoscine in thyrotoxic patients due to its faster onset. Choice C is incorrect because ipratropium is not necessarily better than atropine in bronchial asthma as they have different mechanisms of action. Choice D is incorrect because atropine is actually preferred over tropicamide for fundus examination due to its longer duration of action.
Virilization is characterized by:
- A. excess facial hair.
- B. buffalo hump.
- C. truncal obesity.
- D. gonadal atrophy.
Correct Answer: A
Rationale: The correct answer is A: excess facial hair. Virilization refers to the development of male secondary sexual characteristics in females due to increased androgen levels. Excess facial hair, known as hirsutism, is a classic sign of virilization. Buffalo hump (B) and truncal obesity (C) are associated with Cushing's syndrome, not virilization. Gonadal atrophy (D) refers to the shrinkage of the gonads and is not a typical feature of virilization.