Nokea
Rifampin is a nonspecific CYP450 inducer that may:
- A. Lead to toxic levels of rifampin and must be monitored closely
- B. Cause toxic levels of drugs, such as oral contraceptives, when coadministered
- C. Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure
- D. Cause nonspecific changes in drug metabolism
Correct Answer: C
Rationale: Rifampin induces CYP450, speeding metabolism of drugs like oral contraceptives , reducing efficacy, not causing toxicity or nonspecificity .
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Tom is taking lithium for bipolar disorder. He should be taught to:
- A. Take his lithium with food
- B. Eat a diet with consistent levels of salt (sodium)
- C. Drink at least 2 quarts of water if he is in a hot environment
- D. Monitor blood glucose levels
Correct Answer: B
Rationale: Consistent sodium intake prevents fluctuations in lithium levels.
The nurse is talking with a group of nursing students who are doing clinical hours on the unit. A student asks if all intramuscular (IM) drugs are absorbed the same. What factor would the floor nurse tell the students to affect absorption of the IM administration of drugs?
- A. Perfusion of blood to the subcutaneous tissue
- B. Integrity of the mucous membranes
- C. Environmental temperature
- D. Blood flow to the gastrointestinal tract
Correct Answer: C
Rationale: A cold environmental temperature can cause blood vessels to vasoconstrict and decreases absorption or in a hot environment vasodilate and increase absorption of IM medications. Blood flow to the subcutaneous tissues interferes with subcutaneous injection and blood flow to the gastrointestinal (GI) tract causes alterations in absorption for oral medications. The condition of mucous membranes can interfere with sublingual (under the tongue) and buccal (in the cheek) administration of drugs.
Drug efficacy' refers to..
- A. The range of diseases in which the drug is beneficial
- B. The maximal intensity of response that can be produced by the drug
- C. The therapeutic dose range of the drug
- D. The therapeutic index of the drug
Correct Answer: B
Rationale: Efficacy is defined as the maximum effect a drug can produce, per pharmacological principles.
Choose a drug that is used for both non-Hodgkin's lymphoma and rheumatoid arthritis:
- A. Doxorubicin
- B. Vincristine
- C. Infliximab
- D. Rituximab
Correct Answer: D
Rationale: Rituximab targets CD20 in lymphoma and is also used in rheumatoid arthritis.
A nurse is assessing a client and notes that the client has developed swelling of the eyelids and lips after administration of a prescribed medication. The nurse interprets this finding as specifically indicating which of the following?
- A. Mild allergic reaction
- B. Anaphylactic shock
- C. Angioedema
- D. Drug idiosyncrasy
Correct Answer: C
Rationale: Angioedema is a type of allergic drug reaction manifested by the collection of fluid in the subcutaneous tissues, most commonly affecting the eyelids, lips, mouth, and throat. Allergic reactions can be manifested by a wide range of signs and symptoms such as itching, rashes, and hives. Anaphylactic shock is a serious allergic reaction that requires immediate medical attention. Drug idiosyncrasy describes any unusual or abnormal reaction to a drug, one that is different from the one normally expected.