Select the first choice drug for acute gout:
- A. Colchicine
- B. Indomethacin
- C. Allopurinol
- D. Dexamethasone
Correct Answer: B
Rationale: Indomethacin, an NSAID, is the first-line treatment for acute gout due to its rapid anti-inflammatory action; colchicine is an alternative, while allopurinol is for prophylaxis.
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A nurse is providing information to a client who has a new prescription for Hydrochlorothiazide. Which of the following information should the nurse include?
- A. Take the medication with food.
- B. Plan to take the medication at bedtime.
- C. Expect increased swelling of the ankles.
- D. Fluid intake should be limited in the morning.
Correct Answer: A
Rationale: Taking with food reduces GI upset, a standard instruction for hydrochlorothiazide.
Which of the following glucocorticoid is used for intra-articular injection for treatment of arthrites:
- A. Triamcinolon
- B. Budesonide
- C. Prednisolon
- D. Hydrocortison
Correct Answer: A
Rationale: Triamcinolone is commonly used for intra-articular injections due to its potent anti-inflammatory effects in treating arthritis.
The patient tells the nurse about a new drug being tested to treat the disease she was diagnosed with and asks the nurse whether the doctor can prescribe a medication still in the preclinical phase of testing. What is the nurses best response?
- A. The doctor would have to complete a great deal of paperwork to get approval to prescribe that drug.
- B. Sometimes pharmaceutical companies are looking for volunteers to test a new drug and the doctor could give them your name.
- C. Drugs in the preclinical phase of testing are only tested on animals and so would not be available to you.
- D. Drugs in the preclinical phase of testing are given only to healthy young men and so would not be available to you.
Correct Answer: C
Rationale: During the preclinical phase of testing drugs are tested on animals and are not available to patients. In phase I, the drug is tested on volunteers who are usually healthy young men. It is only in phase III studies that the drug is made available to prescribers who agree to closely monitor patients getting the medication.
A 24-year-old female is prescribed erythromycin for gastroparesis. It is prescribed four times daily due to its short half-life. What is the rationale for such a frequent dosing?
- A. Achieve the steady-state plasma concentration of the drug
- B. Aid more complete distribution of the drug
- C. Avoid the toxicity of the drug because of its low therapeutic index
- D. Ensure that the drug concentration remains constant over time
Correct Answer: C
Rationale: Frequent dosing is required due to erythromycin's short half-life and low therapeutic index, which means a narrow margin between effective and toxic doses, necessitating careful maintenance to avoid toxicity.
Rho immune globulin (RhoGAM) is given to:
- A. Infants born to women who are Rh positive
- B. Sexual partners of Rh-positive women
- C. Rh-negative women after a birth, miscarriage, or abortion
- D. Rh-negative women at 36 weeks gestation
Correct Answer: C
Rationale: RhoGAM prevents Rh sensitization in Rh-negative women post-delivery; it's not for infants , partners , or late gestation alone.
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