Nokea
Steatorrhoea occurs with all of the following EXCEPT:
- A. gastrinoma
- B. congenital defect in gastric lipase
- C. ileal disease with failure to reabsorb bile salts
- D. exocrine pancreatic disease
Correct Answer: B
Rationale: The correct answer is B: congenital defect in gastric lipase. Steatorrhoea is the presence of excess fat in the stool due to malabsorption. Gastrinoma (A), ileal disease (C), and exocrine pancreatic disease (D) can all lead to malabsorption of fats resulting in steatorrhoea. However, a congenital defect in gastric lipase does not directly affect fat absorption in the intestines, making it the exception in this scenario.
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Which of the following drugs is expected to cause anticholinergic adverse effects:
- A. Codeine
- B. Ciprofloxacin
- C. Amitriptyline
- D. Propranolol
Correct Answer: C
Rationale: The correct answer is C: Amitriptyline. Amitriptyline is a tricyclic antidepressant known for its anticholinergic properties, causing dry mouth, constipation, blurred vision, and urinary retention. Anticholinergic effects result from blocking the action of acetylcholine in the parasympathetic nervous system. Codeine (A) is an opioid, Ciprofloxacin (B) is an antibiotic, and Propranolol (D) is a beta-blocker, none of which are expected to cause significant anticholinergic effects.
A patient with a recent drug poisoning is transported to the emergency department. The physician orders (correctly, in this case) administration of pralidoxime as part of the comprehensive emergency treatment plan. Which one of the following best describes who the patient was?
- A. A 13-year-old boy who took an overdose of amphetamine for his ADD/ADHD
- B. A 43-year-old who took an overdose of neostigmine, prescribed for her myasthenia gravis, in a suicide attempt
- C. A 6-year-old who got into the family medicine cabinet and took 10 'adult doses' of her dad's prazosin
- D. A farm/field worker accidentally doused with insecticide from an overflying crop-duster plane
Correct Answer: D
Rationale: The correct answer is D because pralidoxime is used to treat poisoning from organophosphate insecticides, which are commonly used in agriculture. The patient is likely a farm/field worker who was accidentally exposed to insecticide.
A: Amphetamine poisoning does not require pralidoxime.
B: Neostigmine is not an organophosphate insecticide.
C: Prazosin is not an organophosphate insecticide and is unlikely to require pralidoxime in this context.
In summary, the correct answer is D because the patient's exposure to insecticide aligns with the indication for pralidoxime use, while the other choices involve different substances that do not require pralidoxime treatment.
The endocrine gland(s) referred to as the 'master gland' is the:
- A. pancreas
- B. adrenal glands
- C. thyroid gland
- D. pituitary gland
Correct Answer: D
Rationale: The correct answer is D: pituitary gland. The pituitary gland is often referred to as the 'master gland' because it controls the functions of other endocrine glands in the body. It secretes hormones that regulate various bodily functions such as growth, metabolism, and reproduction. It is located at the base of the brain and is divided into two parts: anterior and posterior. The anterior pituitary gland produces and releases several important hormones that influence other endocrine glands. The other choices (A: pancreas, B: adrenal glands, C: thyroid gland) do not have the same broad regulatory control over the endocrine system as the pituitary gland.
Propranolol is contraindicated in:
- A. Angina pectoris
- B. Bronchial asthma
- C. Hypertension
- D. Arrhythmia
Correct Answer: B
Rationale: Propranolol is a non-selective beta-blocker that can cause bronchoconstriction, making it contraindicated in bronchial asthma. It can worsen asthma symptoms by blocking beta-2 receptors in the lungs. Angina pectoris, hypertension, and arrhythmia are conditions where propranolol is commonly used due to its beta-blocking effects on the heart and blood vessels.
Concerning catecholamines, all the following are true EXCEPT:
- A. They contain a catechol nucleus
- B. They act directly on the receptor
- C. Have a short duration of action
- D. Include ephedrine and amphetamine
Correct Answer: D
Rationale: The correct answer is D because ephedrine and amphetamine are not catecholamines. A is correct as catecholamines contain a catechol nucleus. B is true as they act directly on receptors. C is also true since catecholamines have a short duration of action. Therefore, D is the incorrect statement as ephedrine and amphetamine do not fall under the category of catecholamines due to their chemical structure and mode of action.