Nokea
Substrate concentration & velocity curve indicates
- A. Michelis-Mentons equation
- B. Inverse relation
- C. Zero order kinetics
- D. All of the above
Correct Answer: C
Rationale: Substrate concentration vs. velocity in zero-order kinetics shows saturation, unlike first-order (Michaelis-Menten).
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symptomatic and metabolic improvement. Until that time, which of the following might be administered adjunctively to suppress glucocorticoid synthesis?
- A. Cimetidine
- B. Cortisol (massive doses)
- C. Fludrocortisone
- D. Ketoconazole
Correct Answer: D
Rationale: Ketoconazole inhibits glucocorticoid synthesis by blocking adrenal steroidogenesis, useful in Cushing's syndrome management.
Beta blocker are used in all, except
- A. Variant angina
- B. Mild hypertension
- C. Glaucoma
- D. Thyrotoxicosis
Correct Answer: A
Rationale: Beta-blockers worsen variant angina due to unopposed alpha constriction.
A 24 year-old man with a history of substance abuse is suffering from generalized anxiety disorder. Which of the following drugs would be the most suitable for the management of his condition?
- A. Zolpidem
- B. Buspirone
- C. Midazolam
- D. Triazolam
Correct Answer: B
Rationale: Buspirone, a non-benzodiazepine, treats anxiety without dependence risk.
Which of the following is not used for hyperthyroidism:
- A. Triiodthironine
- B. Mercazolil
- C. Diiodthironine
- D. Potassium iodide
Correct Answer: A
Rationale: Triiodothyronine (T3) is a thyroid hormone, not a treatment for hyperthyroidism, unlike the others.
A pharmacology student asks the instructor what an accurate description of a drug agonist is. What is the instructor's best response?
- A. A drug that reacts with a receptor site on a cell preventing a reaction with another chemical on a different receptor site
- B. A drug that interferes with the enzyme systems that act as catalyst for different chemical reactions
- C. A drug that interacts directly with receptor sites to cause the same activity that a natural chemical would cause at that site
- D. A drug that reacts with receptor sites to block normal stimulation, producing no effect
Correct Answer: C
Rationale: Agonists are drugs that produce effects similar to those produced by naturally occurring neurotransmitters, hormones, or other substances found in the body. Noncompetitive antagonists are drugs that react with some receptor sites preventing the reaction of another chemical with a different receptor site. Drug-enzyme interactions interfere with the enzyme systems that stimulate various chemical reactions.