Nokea
There is a narrow margin between first appearance of adverse reaction to AChE inhibitors and serious toxic effects. Adverse reactions that require immediate action include:
- A. Dizziness and headache
- B. Nausea
- C. Decreased salivation
- D. Fasciculations of voluntary muscles
Correct Answer: D
Rationale: Fasciculations indicate potential cholinergic crisis, requiring urgent intervention.
You may also like to solve these questions
Which of the following statements about NSAIDs is false?
- A. NSAIDs are not recommended during pregnancy
- B. NSAIDs increase renal blood flow
- C. NSAIDs reduce the therapeutic effect of SSRIs
- D. NSAIDs have a hypocoagulability effect
Correct Answer: B
Rationale: NSAIDs decrease renal blood flow by inhibiting prostaglandins, making this statement false.
In post menopausal women who are receiving estrogen replacement therapy, medroxyprogesterone is administered concurrently to reduce the risk of:
- A. Atherosclerosis
- B. Endometrial cancer
- C. Hypertension
- D. Osteoporosis
Correct Answer: B
Rationale: Progestins like medroxyprogesterone reduce estrogen-induced endometrial hyperplasia and cancer risk.
What does the provider understand about the issue of 'Diabetic Renal Protection' with angiotensin-converting enzyme (ACE) medications? Diabetes mellitus patients:
- A. Have a reduced rate of renal progression, but still need to be discontinued when advanced renal issues present
- B. Who start these medications never progress to renal nephropathy
- C. With early renal dysfunction will see it reverse when on ACE medications
- D. Without renal issues are the only ones who benefit from ACE protection
Correct Answer: A
Rationale: ACE inhibitors slow renal progression in diabetes but are stopped in advanced renal failure.
Which of the following are poorly perfused tissues?
- A. Heart
- B. Brain
- C. Liver
- D. Kidneys
Correct Answer: B
Rationale: This appears to be a trick question; heart, brain, liver, and kidneys are well-perfused. Assuming intent was poorly perfused, none fit, but B (Brain) is least correct here as it's well-perfused.
All of the following statements about efficacy and potency are true EXCEPT:
- A. Efficacy is usually a more important clinical consideration than potency
- B. Efficacy is the maximum effect of a drug
- C. Potency is a comparative measure, refers to the different doses of two drugs that are needed to produce the same effect
- D. The ED50 is a measure of drug's efficacy
Correct Answer: D
Rationale: ED50 measures potency (dose for 50% effect), not efficacy (maximal effect).