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Which condition is an example of Type IV hypersensitivity?
- A. Multiple sclerosis
- B. Grave's disease
- C. Anaphylaxis
- D. Eczema
Correct Answer: A
Rationale: The correct answer is A: Multiple sclerosis. Type IV hypersensitivity involves T cell-mediated immune reactions, leading to tissue damage. In multiple sclerosis, myelin sheath destruction is caused by activated T cells attacking self-antigens.
Incorrect choices:
B: Grave's disease is an example of Type II hypersensitivity involving autoantibodies targeting specific cells.
C: Anaphylaxis is a Type I hypersensitivity reaction mediated by IgE antibodies causing rapid and severe allergic reactions.
D: Eczema is a chronic inflammatory skin condition involving complex immune mechanisms not specific to Type IV hypersensitivity.
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An 80-year-old man falls and suffers a compound fracture of the femur. Which immediate action is most appropriate?
- A. Position him flat on his back.
- B. Apply a tourniquet on the leg.
- C. Carefully splint the leg as it is.
- D. Carefully straighten the leg.
Correct Answer: C
Rationale: The correct answer is C: Carefully splint the leg as it is. This is the most appropriate immediate action because splinting the leg as it is will help stabilize the fracture and prevent further injury or damage to surrounding tissues. Moving or straightening the leg (option D) could worsen the fracture and cause more pain. Positioning him flat on his back (option A) may not provide enough support and could lead to additional complications. Applying a tourniquet (option B) is not necessary and could potentially cut off blood flow to the leg, causing more harm. Splinting the leg as it is will help maintain alignment and reduce the risk of further damage until proper medical care can be provided.
Monoclonal antibodies can be used to:
- A. Block the proliferation of cancer cells
- B. Target cancer cells for destruction
- C. Inhibit inflammatory immune responses
- D. All of the above
Correct Answer: D
Rationale: The correct answer is D because monoclonal antibodies have the ability to block the proliferation of cancer cells by targeting specific antigens on the cancer cells. They can also target cancer cells for destruction through various mechanisms such as antibody-dependent cell-mediated cytotoxicity. Additionally, monoclonal antibodies can inhibit inflammatory immune responses by neutralizing pro-inflammatory mediators or blocking immune cell activation pathways. Therefore, all the options A, B, and C are correct, making D the correct answer.
A nurse has educated a client on an epinephrine autoinjector. What statement by the client indicates additional instruction is needed?
- A. I don't need to go to the hospital after using it.
- B. I must carry two autoinjectors with me at all times.
- C. I will write the expiration date on my calendar.
- D. This can be injected right through my clothes.
Correct Answer: A
Rationale: The correct answer is A. If the client states they don't need to go to the hospital after using the epinephrine autoinjector, additional instruction is needed. The rationale is that after using an epinephrine autoinjector, it is crucial to seek medical attention immediately due to the potential for severe allergic reactions. Choice B is incorrect because carrying two autoinjectors is recommended in case the first dose is not effective. Choice C is incorrect as it demonstrates good practice in tracking the expiration date. Choice D is incorrect as it is acceptable to inject through clothes in an emergency situation.
Determine the following diseases that are not thought to be an autoimmune disease.
- A. Rheumatoid arthritis
- B. Multiple sclerosis
- C. Cancer of the bone marrow
- D. Insulin-dependent diabetes
Correct Answer: C
Rationale: The correct answer is C, Cancer of the bone marrow. Autoimmune diseases occur when the immune system mistakenly attacks healthy cells. Rheumatoid arthritis, multiple sclerosis, and insulin-dependent diabetes are autoimmune diseases where the immune system targets specific tissues or organs. Cancer of the bone marrow, on the other hand, is a result of uncontrolled cell growth and division, not a malfunction of the immune system attacking the body's own tissues. Therefore, it is not considered an autoimmune disease.
Which scientist is credited with identifying Toll-like receptors (TLRs) in innate immunity?
- A. Paul Ehrlich
- B. Jules Hoffman
- C. Edward Jenner
- D. Louis Pasteur
Correct Answer: B
Rationale: The correct answer is B: Jules Hoffman. He is credited with identifying Toll-like receptors (TLRs) in innate immunity. Hoffman's research provided crucial insights into how the immune system recognizes pathogens and triggers immune responses. Paul Ehrlich is known for his work on antibodies, Edward Jenner for developing the smallpox vaccine, and Louis Pasteur for his contributions to germ theory and vaccination. However, none of them are specifically associated with the discovery of Toll-like receptors in innate immunity.