Nokea
Which of the following cephalosporins has in vitro activity against anaerobic gram negative bacteria such as Bacteroides fragilis?
- A. Cefdinir
- B. Cefuroxime
- C. Cefazolin
- D. Cefepime
Correct Answer: B
Rationale: The correct answer is B: Cefuroxime. Cefuroxime is a second-generation cephalosporin that has demonstrated in vitro activity against anaerobic gram-negative bacteria like Bacteroides fragilis. This is due to its broader spectrum of activity compared to other choices.
A: Cefdinir is a third-generation cephalosporin with limited activity against anaerobic gram-negative bacteria.
C: Cefazolin is a first-generation cephalosporin primarily effective against aerobic gram-positive bacteria.
D: Cefepime is a fourth-generation cephalosporin with limited activity against anaerobic gram-negative bacteria.
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Which of the following drug is a radical curative in plasmodium vivax malaria and is used as prophylaxis for malaria at Chloroquine sensitive regions
- A. Quinine
- B. Primaquine
- C. Mefloquine
- D. Chloroquine
Correct Answer: B
Rationale: The correct answer is B: Primaquine. Primaquine is a radical curative drug for Plasmodium vivax malaria, targeting the liver stage of the parasite to prevent relapse. It is also used as prophylaxis in Chloroquine sensitive regions due to its effectiveness against both the liver and blood stages of the parasite. Quinine (A) is mainly used for treating severe malaria. Mefloquine (C) is used for prophylaxis but not as a radical curative for Plasmodium vivax. Chloroquine (D) is effective against Plasmodium vivax but not as a radical curative.
Which statement concerning the testes is true?
- A. The lymphatic vessels of the testes drain into the abdominal lymph nodes.
- B. The vas deferens is located along the inferior portion of each testis.
- C. The right testis is lower than the left because the right spermatic cord is longer.
- D. The cremaster muscle contracts in response to cold and draws the testicles closer to the body.
Correct Answer: D
Rationale: The correct answer is D: The cremaster muscle contracts in response to cold and draws the testicles closer to the body. This is true because the cremaster muscle is responsible for regulating the position of the testicles in response to temperature changes to maintain optimal conditions for sperm production. The other choices are incorrect because: A: The lymphatic vessels of the testes drain into the para-aortic lymph nodes, not the abdominal lymph nodes. B: The vas deferens is a duct that carries sperm from the testes to the urethra, not located along the inferior portion of each testis. C: The difference in height between the testes is due to differences in the descent of the testes during fetal development, not the length of the spermatic cord.
Which of the following drugs for treatment of leprosy can cause hemolysis * especially in patients with G6PD deficiency?
- A. Dapsone
- B. Rifampicin
- C. Clofazimine
- D. None of these
Correct Answer: A
Rationale: Rationale:
1. Dapsone is a known cause of hemolysis in patients with G6PD deficiency due to oxidative stress.
2. Dapsone triggers the release of reactive oxygen species, leading to hemolysis in G6PD-deficient individuals.
3. Rifampicin and clofazimine do not have a direct association with hemolysis in G6PD deficiency.
4. Option D is incorrect as dapsone is a well-established drug associated with hemolysis in G6PD-deficient individuals.
Which of the following drugs valuable in the treatment of edema and metabolic alkalosis?
- A. Digoxin
- B. Spironolactone
- C. Dobutamine
- D. Acetazolamide
Correct Answer: D
Rationale: The correct answer is D: Acetazolamide. Acetazolamide is a carbonic anhydrase inhibitor that helps in the treatment of edema and metabolic alkalosis by promoting diuresis and increasing renal excretion of bicarbonate. It is effective in treating conditions associated with fluid retention and alkalosis.
A: Digoxin is a cardiac glycoside used to treat heart conditions like heart failure and atrial fibrillation, not edema or metabolic alkalosis.
B: Spironolactone is a potassium-sparing diuretic commonly used for conditions like hypertension and heart failure, but not specifically for metabolic alkalosis.
C: Dobutamine is a beta-adrenergic agonist used in acute heart failure or shock situations, not for edema or alkalosis.
In summary, Acetazolamide is the correct choice as it directly targets edema and metabolic alkalosis by affecting renal excretion of bicarbonate. Other options are
The penicillin G preparation with the longest duration of action is: *
- A. Benzathine penicillin
- B. Sodium penicillin
- C. Potassium penicillin
- D. Procaine penicillin
Correct Answer: D
Rationale: The correct answer is D: Procaine penicillin. Procaine penicillin is a long-acting penicillin formulation due to the addition of procaine, which slows down the release of penicillin into the bloodstream. This results in a prolonged duration of action compared to benzathine, sodium, and potassium penicillin. Benzathine penicillin is also long-acting but primarily used for prevention, not treatment. Sodium and potassium penicillin are not formulated for extended action, making them less suitable for long-term treatment. Therefore, D is the best choice for long-lasting penicillin therapy.