Nokea
Which of the following correctly explains an epitope?
- A. Region of antibody that binds with antigen
- B. Region of antigen that elicit secretion of specific antibody
- C. Heavy chain of an antibody
- D. V-region of the light chain of antibody
Correct Answer: B
Rationale: Explanation:
An epitope is a specific region on an antigen that elicits the immune response and triggers the production of a specific antibody. Therefore, choice B is correct as it accurately defines an epitope. Choices A, C, and D are incorrect because they do not accurately describe what an epitope is. Choice A refers to the paratope, the region of the antibody that binds to the epitope. Choice C refers to a component of the antibody structure, and choice D refers to a specific region of the antibody structure.
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Which of the following statements about the 2009 H1N1 pandemic is NOT true
- A. Caused by a virus originated from 4 different strains
- B. Individuals over 60 were especially affected
- C. A level 6 pandemic phase was declared by WHO in June 2009
- D. 2009 H1N1 is considered moderately virulent in terms of severity of disease
Correct Answer: B
Rationale: The correct answer is B. Individuals over 60 were not especially affected by the 2009 H1N1 pandemic. This is because older individuals had some level of immunity due to previous exposure to similar strains. The other choices are incorrect because: A: The 2009 H1N1 virus originated from a combination of 2 different strains, not 4. C: WHO declared a level 6 pandemic phase in June 2009. D: The 2009 H1N1 virus was considered less virulent compared to other strains.
The process of somatic hypermutation:
- A. Can lead to the formation of antibodies with higher affinity for the antigen
- B. Occurs mainly in the CDR regions of immunoglobulin heavy and light chain genes
- C. Occurs in germinal centres
- D. All of the above are correct
Correct Answer: D
Rationale: The correct answer is D because somatic hypermutation can lead to the formation of antibodies with higher affinity for the antigen by introducing point mutations in the variable regions of immunoglobulin genes. This process mainly occurs in the complementarity-determining regions (CDRs) of immunoglobulin heavy and light chain genes, which are critical for antigen binding. Somatic hypermutation takes place in the germinal centers of secondary lymphoid organs, where B cells undergo rapid proliferation and selection based on antigen binding affinity. Therefore, all the statements in choices A, B, and C are correct, making option D the right answer.
Which of the following is the most important factor in the nursing management of a client with CFS?
- A. Teaching the client how to avoid aggravating the disease
- B. Informing the client about the drug therapy that will provide significant improvement
- C. Advising the client to alter the diet and environment
- D. Educating the client about the disease process and its limitations
Correct Answer: D
Rationale: Educating the client about the disease process and its limitations helps them manage symptoms and improve quality of life.
What is the medical term for an abnormal accumulation of blood in a tissue or organ?
- A. Hematoma
- B. Thrombosis
- C. Embolus
- D. Hemorrhage
Correct Answer: A
Rationale: The correct answer is A: Hematoma. A hematoma is an abnormal collection of blood within tissues. This occurs due to broken blood vessels and can lead to swelling and localized pain. Thrombosis (B) is the formation of a blood clot within a blood vessel, not an accumulation of blood in tissue. An embolus (C) is a blood clot that travels through the bloodstream and gets lodged in a blood vessel. Hemorrhage (D) refers to the excessive bleeding from blood vessels. In this case, the most appropriate term for an abnormal accumulation of blood in a tissue is hematoma.
Which of the following sentences concerned with lymph node structure is incorrect?
- A. naïve B lymphocytes are found in the cortex
- B. naïve T lymphocytes are found in the paracortex
- C. naïve lymphocytes enter the lymph node through the efferent lymphatic vessel
- D. Antigens can enter the lymph node through afferent lymphatic vessels
Correct Answer: C
Rationale: Rationale:
C is incorrect because naïve lymphocytes actually enter the lymph node through the afferent lymphatic vessel, not the efferent. A carries lymphocytes into the lymph node, and D is true since antigens enter through afferent vessels. B is correct, as naïve T cells are found in the paracortex.