Genitourinary System Quizlet Related

Review Genitourinary System Quizlet related questions and content

Which of the following diuretics than can cause gynecomastia, hirsutism and menstrual disturbances as adverse reactions?

  • A. Hydrochlorothiazide
  • B. Bumetanide
  • C. Acetazolamide
  • D. Spironolactone
Correct Answer: D

Rationale: Step-by-step rationale:
1. Spironolactone is a potassium-sparing diuretic that acts as an aldosterone antagonist.
2. Aldosterone antagonism can lead to anti-androgenic effects, causing gynecomastia and hirsutism in males and menstrual disturbances in females.
3. Hydrochlorothiazide (A) is a thiazide diuretic known for electrolyte imbalances, not these specific side effects.
4. Bumetanide (B) is a loop diuretic that primarily affects electrolytes, not causing hormonal side effects.
5. Acetazolamide (C) is a carbonic anhydrase inhibitor, usually associated with metabolic acidosis, not hormonal disturbances.

Summary:
Spironolactone (D) is the correct answer due to its aldosterone antagonist properties causing hormonal side effects. The other choices do not have the same mechanism of action and are not associated with gynecomastia,