Nokea
Which of the following is an alfa glucosidase inhibitor:
- A. Rosiglitazone
- B. Stagliptine
- C. Exenatide
- D. Acarbose
Correct Answer: D
Rationale: Acarbose inhibits alpha-glucosidase enzymes in the intestine, delaying carbohydrate digestion and absorption, thus reducing postprandial glucose levels.
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Patient teaching related to amlodipine includes:
- A. Increase calcium intake to prevent osteoporosis from a calcium blockade.
- B. Do not crush the tablet; it must be given in liquid form if the patient has trouble swallowing it.
- C. Avoid grapefruit juice as it affects the metabolism of this drug.
- D. Rise slowly from a supine position to reduce orthostatic hypotension.
Correct Answer: C
Rationale: Grapefruit juice inhibits CYP3A4, increasing amlodipine levels.
During which phase of pharmacokinetics could a significant drug-drug interaction occur, resulting in one drug stimulating or blocking the metabolism of the other drug?
- A. Absorption
- B. Distribution
- C. Biotransformation
- D. Excretion
Correct Answer: C
Rationale: During biotransformation, a drug may be metabolized quicker if taken at the same time as another drug, and higher doses of the drug will be needed to achieve the desired effect. During absorption, one drug can prevent or accelerate absorption of the other drug. During distribution, one drug competes for the protein-binding site of another drug so the second drug cannot be transported to the reactive tissue. During excretion, one drug competes for excretion with the other drug, leading to accumulation and toxic effects of one of the drugs.
Vincristine toxicity frequently presents as:
- A. Anemia
- B. Neutropenia
- C. Thrombocytopenia
- D. Polyneuritis
Correct Answer: D
Rationale: Vincristine commonly causes neurotoxicity, including polyneuritis.
Once phosphorylated, the intracellular segment of a receptor tyrosine kinase
- A. Activates adenylate cyclase
- B. Causes dissociation of the ligand from an allosteric binding site
- C. Terminates intracellular signaling cascades
- D. Allows docking of intracellular proteins involved in signal transduction
Correct Answer: D
Rationale: Phosphorylation enables docking of signaling proteins, initiating transduction cascades.
Licorice root is a common treatment for dyspepsia. Drug interactions with licorice include:
- A. Antihypertensives, diuretics, and digoxin
- B. Antidiarrheals, antihistamines, and omeprazole
- C. Penicillin antibiotic class and benzodiazepines
- D. None of the above
Correct Answer: A
Rationale: Licorice affects potassium levels and blood pressure, interacting with antihypertensives, diuretics, and digoxin.