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Which of the following is true about procainamide and its dosing schedule?
- A. It produces bradycardia and should be used cautiously in patients with cardiac conditions that a slower heart rate might worsen.
- B. Gastrointestinal adverse effects are common so the drug should be taken with food.
- C. Adherence can be improved by using a sustained release formulation that can be given once daily.
- D. Doses of this drug should be taken evenly spaced around the clock to keep an even blood level.
Correct Answer: D
Rationale: Even spacing maintains steady procainamide levels.
You may also like to solve these questions
Only free drugs can act on target sites and can be eliminated.
- A. TRUE
- B. FALSE
Correct Answer: A
Rationale: True; only free (unbound) drugs can interact with target sites and be filtered/excreted, as bound drugs are pharmacologically inactive.
A pharmacology student asks the instructor what an accurate description of a drug agonist is. What is the instructors best response?
- A. A drug that reacts with a receptor site on a cell preventing a reaction with another chemical on a different receptor site
- B. A drug that interferes with the enzyme systems that act as catalyst for different chemical reactions
- C. A drug that interacts directly with receptor sites to cause the same activity that a natural chemical would cause at that site
- D. A drug that reacts with receptor sites to block normal stimulation, producing no effect
Correct Answer: C
Rationale: Agonists are drugs that produce effects similar to those produced by naturally occurring neurotransmitters, hormones, or other substances found in the body. Noncompetitive antagonists are drugs that react with some receptor sites preventing the reaction of another chemical with a different receptor site. Drug-enzyme interactions interfere with the enzyme systems that stimulate various chemical reactions.
Which cytochrome is responsible for drug metabolism?
- A. P-450
- B. C-3b
- C. C-3a
- D. C-2a
Correct Answer: A
Rationale: Cytochrome P-450 enzymes in the liver are primary for drug metabolism.
Which of the following statements about aminoglycosides is false?
- A. They have short half-lives
- B. They are bactericidal
- C. They exacerbate weakness in myasthenia gravis patients
- D. None of the Above
Correct Answer: D
Rationale: All statements are true: aminoglycosides have short half-lives (2-3 hours), are bactericidal, and can worsen myasthenia gravis by neuromuscular blockade.
Which statement is not correct about rosiglitazon:
- A. Enhance insulin production by pancreatic beta cells
- B. Increase senstivitiy towards insulin
- C. Increase uptake of glucose by tissues
Correct Answer: A
Rationale: Rosiglitazone increases insulin sensitivity, not insulin production, via PPAR-gamma activation.