NCLEX Questions Gastrointestinal System Related

Review NCLEX Questions Gastrointestinal System related questions and content

Which of the following mechanisms most accurately describes how pseudo-membranous colitis caused by Clostridium difficile is produced?

  • A. elaboration of an enterotoxin following colonization of the colon
  • B. ingestion of a preformed toxin
  • C. invasion and destruction of mucosa by the organism
  • D. host immune response to the organism
Correct Answer: A

Rationale: The correct answer is A because Clostridium difficile produces toxins, specifically enterotoxins, which cause damage to the intestinal mucosa leading to pseudo-membranous colitis. The organism colonizes the colon and then elaborates the toxins, which disrupt the mucosal barrier.

Choice B is incorrect as there is no preformed toxin ingested; the toxin is produced by the organism after colonization. Choice C is incorrect as Clostridium difficile does not invade and destroy the mucosa directly. Choice D is incorrect as the host immune response is a consequence of the toxin production, not the primary mechanism of disease.