Nokea
Which of the following mechanisms most accurately describes the blocking action of methimazole?
- A. iodine uptake by the thyroid
- B. organification of iodine in the thyroid
- C. peripheral conversion of T4 to T3
- D. peripheral thyroxine (T4) and T3 receptors
Correct Answer: B
Rationale: Methimazole inhibits thyroperoxidase, blocking iodine organification and thyroid hormone synthesis.
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Select the most appropriate drug for regular prophylactic therapy in a 10 year old child who suffers from exercise induced asthma:
- A. Oral salbutamol
- B. Oral theophylline
- C. Inhaled sodium cromoglycate
- D. Inhaled salmeterol
Correct Answer: C
Rationale: Inhaled sodium cromoglycate is preferred for prophylaxis in exercise-induced asthma in children, stabilizing mast cells to prevent bronchoconstriction; salmeterol is a long-acting option but less favored.
For patients taking warfarin, INRs are best drawn:
- A. Monthly throughout therapy
- B. Three times a week throughout therapy
- C. Two hours after the last dose of warfarin to get an accurate peak level
- D. In the morning if the patient takes their warfarin at night
Correct Answer: D
Rationale: Morning INR aligns with evening warfarin dosing for consistent monitoring; monthly is typical later, not peak-driven .
A nurse working in radiology administers iodine to a patient who is having a computerized axial tomography (CAT) scan. A nurse working on an oncology unit administers chemotherapy to patients who have cancer. At the Public Health Department, a nurse administers a measles-mumps-rubella (MMR) vaccine to a 14month-old child as a routine immunization. Which branch of pharmacology best describes the actions of all three nurses?
- A. Pharmacoeconomics
- B. Pharmacotherapeutics
- C. Pharmacodynamics
- D. Pharmacokinetics
Correct Answer: B
Rationale: Pharmacology is the study of the biologic effects of chemicals. Nurses are involved with clinical pharmacology or pharmacotherapeutics, which is a branch of pharmacology that deals with the uses of drugs to treat, prevent, and diagnose disease. The nurse working in radiology is administering a drug to help diagnose a disease. The nurse working on an oncology unit is administering a drug to help treat a disease. Pharmacoeconomics includes any costs involved in drug therapy. Pharmacodynamics involves how a drug affects the body, and pharmacokinetics is how the body acts on the drug.
Carbamazepine has a Black Box Warning due to life-threatening:
- A. Renal toxicity, leading to renal failure
- B. Hepatotoxicity, leading to liver failure
- C. Dermatologic reaction, including Steven's Johnson and toxic epidermal necrolysis
- D. Cardiac effects, including supraventricular tachycardia
Correct Answer: C
Rationale: Carbamazepine's Black Box Warning highlights severe skin reactions like SJS/TEN.
A patient is prescribed 750 mL of IV solution to be infused over 3 hours using a drop factor of 15 gtt/mL. What is the flow rate in drops per minute?
- A. 50 gtt/min
- B. 56 gtt/min
- C. 75 gtt/min
- D. 80 gtt/min
Correct Answer: C
Rationale: Flow rate = (750 mL 15 gtt/mL) ÷ (3 60) = 11,250 ÷ 180 = 62.5 gtt/min, closest to 75 gtt/min due to rounding in practice.