Nokea
Which of the following produced only by large amounts of glucocorticoids?
- A. Normal responsiveness of fat depots to norepinephrine
- B. Maintenance of normal vascular reactivity
- C. Increased excretion of a water load
- D. Inhibition of the inflammatory response
Correct Answer: D
Rationale: The correct answer is D because glucocorticoids inhibit the inflammatory response by suppressing the immune system. Glucocorticoids reduce inflammation by blocking the production of inflammatory substances like prostaglandins and cytokines. This effect is only observed in large amounts of glucocorticoids. Choices A, B, and C are not produced exclusively by large amounts of glucocorticoids. Normal responsiveness of fat depots to norepinephrine and maintenance of normal vascular reactivity are not directly related to glucocorticoids in large amounts. Increased excretion of a water load is more influenced by other factors such as hydration status and renal function.
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The endocrine gland(s) that sits on top of the kidneys and secretes both metabolic stabilizers and stress regulators:
- A. pancreas
- B. adrenal glands
- C. thyroid gland
- D. pituitary gland
Correct Answer: B
Rationale: The correct answer is B: adrenal glands. The adrenal glands are located on top of the kidneys and secrete hormones like cortisol and adrenaline, which play a key role in regulating metabolism and responding to stress. The pancreas (A) primarily regulates blood sugar levels. The thyroid gland (C) regulates metabolism and growth. The pituitary gland (D) controls several other endocrine glands but is not located on top of the kidneys and does not secrete metabolic stabilizers and stress regulators.
Which of the following is NOT true of Cushing syndrome?
- A. trunk (torso) becomes obese
- B. basic blood pH
- C. moon-shaped face
- D. hyposecretion of adrenal cortex hormones.
Correct Answer: D
Rationale: Step-by-step rationale:
1. Cushing syndrome is characterized by hypersecretion of adrenal cortex hormones, not hyposecretion.
2. Option D states hyposecretion, which is incorrect for Cushing syndrome.
3. Trunk obesity, moon-shaped face, and alkalosis (basic blood pH) are characteristic features of Cushing syndrome.
4. Thus, option D is the correct answer because it is not a true characteristic of Cushing syndrome.
Summary:
Option D is incorrect because Cushing syndrome is associated with hypersecretion of adrenal cortex hormones, not hyposecretion. Options A, B, and C are true characteristics of Cushing syndrome, making them incorrect choices.
Each of the following parasympathomimetic drugs is correctly matched with an appropriate pharmacological action EXCEPT:
- A. Methacholine - vasodilation of peripheral blood vessels
- B. Neostigmine - stimulation of skeletal muscles
- C. Pilocarpine - increased sweat secretion
- D. Bethanechol - increased intraocular pressure
Correct Answer: D
Rationale: The correct answer is D. Bethanechol is a parasympathomimetic drug that primarily acts on muscarinic receptors in the bladder and gastrointestinal tract, causing increased smooth muscle contraction and promoting urination and improved GI motility. It does not affect intraocular pressure.
A, B, and C are incorrect:
A: Methacholine - acts as a muscarinic agonist causing bronchoconstriction, not vasodilation.
B: Neostigmine - inhibits acetylcholinesterase leading to increased acetylcholine levels, enhancing neuromuscular transmission, not directly stimulating skeletal muscles.
C: Pilocarpine - acts on muscarinic receptors in the eye, causing miosis and increased aqueous humor outflow, not increased sweat secretion.
Which one of the following drugs can trigger severe bronchospasm in a patient who has asthma?
- A. Atropine
- B. Isoproterenol
- C. Phenylephrine
- D. Propranolol
Correct Answer: D
Rationale: The correct answer is D: Propranolol. Propranolol is a non-selective beta-blocker that can trigger severe bronchospasm in patients with asthma by blocking beta-2 receptors in the lungs, leading to bronchoconstriction. Atropine (A) is an anticholinergic drug that dilates the airways. Isoproterenol (B) is a beta-agonist that relaxes the airway smooth muscles. Phenylephrine (C) is a sympathomimetic drug that constricts blood vessels, not airways.
Antidiuretic hormone (ADH) and oxytocin:
- A. are secreted by the neurohypophysis.
- B. are mineralocorticoids.
- C. are secreted by the islets of Langerhans.
- D. stimulate the kidney to excrete Na+ and water.
Correct Answer: A
Rationale: Step-by-step rationale for choice A being correct:
1. ADH and oxytocin are peptide hormones.
2. They are synthesized in the hypothalamus.
3. They are transported and stored in the neurohypophysis.
4. Upon stimulation, they are released from the neurohypophysis.
5. Therefore, both ADH and oxytocin are indeed secreted by the neurohypophysis.
Summary of why other choices are incorrect:
B: ADH and oxytocin are not mineralocorticoids; they regulate water balance and uterine contractions, respectively.
C: Islets of Langerhans secrete insulin and glucagon, not ADH or oxytocin.
D: ADH promotes water reabsorption in the kidneys, opposite to excreting Na+ and water.