Genitourinary System Diseases Related

Review Genitourinary System Diseases related questions and content

Which of the following semisynthetic penicillins which has an extended * spectrum of activity against many gram negative bacilli, is acid resistant but not penicillinase resistant?:

  • A. Cloxacillin
  • B. Amoxicillin
  • C. Phenoxymethyl penicillin
  • D. Piperacillin
Correct Answer: D

Rationale: Step 1: Piperacillin is a semisynthetic penicillin with extended spectrum against gram-negative bacilli.
Step 2: It is acid-resistant, meaning it can withstand acidic environments in the stomach.
Step 3: However, it is not penicillinase-resistant, making it susceptible to penicillinase enzymes.
Step 4: Cloxacillin (A) and Amoxicillin (B) are penicillinase-resistant but do not have extended gram-negative activity.
Step 5: Phenoxymethyl penicillin (C) is neither acid-resistant nor penicillinase-resistant.
In summary, Piperacillin is the correct choice due to its extended spectrum against gram-negative bacilli and acid resistance, despite not being penicillinase-resistant.