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Which of the following viruses is most susceptible to acyclovir?:
- A. Herpes simplex Type 1 virus
- B. Herpes simplex Type 2 virus
- C. Varicella-zoster virus
- D. Epstein-Barr virus
Correct Answer: A
Rationale: Acyclovir is an antiviral medication that specifically targets viruses that belong to the herpes virus family by inhibiting their replication. Herpes simplex Type 1 virus is most susceptible to acyclovir because it has a thymidine kinase enzyme that activates acyclovir into its active form, which then interferes with viral DNA synthesis. Herpes simplex Type 2 virus also has this enzyme, but it is not as effective against acyclovir compared to Type 1. Varicella-zoster virus and Epstein-Barr virus do not have the thymidine kinase enzyme necessary for acyclovir activation, making them less susceptible to the drug.
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A patient with HIV-AIDS being treated with combined antiviral drugs and immunosuppressive agents, develops an opportunistic infection caused by Pneumocystis carinii. Which of the following drugs most likely be used in the treatment of pulmonary infection caused by P. carinii?
- A. Metronidazole
- B. Carbenicillin
- C. Trimethoprim/Sulfamethoxazole
- D. Penicillin G
Correct Answer: C
Rationale: The correct answer is C: Trimethoprim/Sulfamethoxazole. This combination is the first-line treatment for Pneumocystis carinii pneumonia in patients with HIV-AIDS due to its efficacy against the organism. Trimethoprim inhibits dihydrofolate reductase, while sulfamethoxazole inhibits dihydropteroate synthase, both essential enzymes for folate synthesis in bacteria and protozoa like P. carinii. Metronidazole (A) is used for anaerobic infections, Carbenicillin (B) is a penicillinase-resistant penicillin used for Gram-negative infections, and Penicillin G (D) is a narrow-spectrum antibiotic mainly used for Gram-positive infections.
A nurse is caring for a patient with impaired renal which the nurse should monitor the patient?
- A. Accumulation of wastes
- B. The nurse should facilitate collection of what
- C. Retention of potassium
- D. Depletion of calcium
Correct Answer: A
Rationale: The correct answer is A because impaired renal function can lead to the accumulation of wastes in the body, causing toxicity. Monitoring this is crucial for the patient's overall health. Choice B is incorrect as it does not directly relate to the consequences of impaired renal function. Choice C, retention of potassium, is also incorrect as it is a specific outcome of impaired renal function and not the primary focus of monitoring. Choice D, depletion of calcium, is incorrect as impaired renal function is more likely to lead to hypercalcemia rather than hypocalcemia. Therefore, the nurse should prioritize monitoring the accumulation of wastes in a patient with impaired renal function.
A 28 year old male patient present with a painless sore in his penis and blood * test confirms Treponema pallidum. Which of the following agent is the treatment of choice that can be given as a single dose?
- A. Benzathine penicillin
- B. Ceftriaxone
- C. Vancomycin
- D. Aztreonam
Correct Answer: A
Rationale: The correct answer is A: Benzathine penicillin. The treatment of choice for syphilis caused by Treponema pallidum is penicillin. Benzathine penicillin is preferred due to its long-acting nature, providing sustained therapeutic levels. It is given as a single dose for early-stage syphilis. Ceftriaxone, vancomycin, and aztreonam are not effective against Treponema pallidum and are not recommended for the treatment of syphilis. Benzathine penicillin remains the first-line treatment due to its efficacy and established effectiveness against syphilis.
What is the most appropriate response regarding the use of salt substitute for Susan on a salt-restricted diet?
- A. Yes, there are some very good salt substitutes available and they do make the food taste better.
- B. Salt substitutes contain potassium and should be avoided.
- C. You may use a salt substitute now but may need to give it up later.
- D. Why don’t you try seasoning your food with soy sauce or beef bouillon?
Correct Answer: B
Rationale: The correct answer is B because salt substitutes often contain potassium, which can be harmful for individuals on a salt-restricted diet, especially those with kidney issues. Excessive potassium intake can lead to dangerous health complications.
Choice A is incorrect because while some salt substitutes may enhance flavor, the primary concern with their use is the potassium content, not taste improvement.
Choice C is incorrect as it suggests a temporary use of salt substitute, which may not be advisable due to the potential potassium-related health risks.
Choice D is incorrect as it suggests alternative seasonings that may not address the issue of potassium intake from salt substitutes.
What is the most common cause of acute pyelonephritis resulting from an ascending infection from the lower urinary tract?
- A. The kidney is scarred and fibrotic.
- B. The organism is resistant to antibiotics.
- C. There is a preexisting abnormality of the urinary tract.
- D. The patient does not take all of the antibiotics for treatment of a UTI.
Correct Answer: C
Rationale: The correct answer is C. The most common cause of acute pyelonephritis from an ascending infection is a preexisting abnormality of the urinary tract. This abnormality can lead to urine stasis, making it easier for bacteria to ascend from the lower urinary tract to the kidneys. Choices A and B are incorrect because scarred kidneys and antibiotic resistance do not typically cause acute pyelonephritis. Choice D is incorrect as non-compliance with antibiotics may contribute to recurrent infections but is not the most common cause of pyelonephritis.