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Why are tricyclic antidepressants infrequently used?

  • A. Have many side effects
  • B. Have many interactions with other medications
  • C. Can cause cardiac problems
  • D. Lethal in overdose
Correct Answer: A

Rationale: The correct answer is A because tricyclic antidepressants have numerous side effects such as dry mouth, constipation, weight gain, and sedation. These side effects can be intolerable for patients, leading to poor adherence. Choices B, C, and D are incorrect because while tricyclic antidepressants can have interactions with other medications, cause cardiac problems, and be lethal in overdose, these factors alone do not fully explain why they are infrequently used compared to other antidepressant options. The primary reason for their limited use lies in their significant side effect profile.