A protective response to Leishmania parasites is most likely to occur when:
Correct Answer: C
Rationale: The correct answer is C because in response to Leishmania parasites, the activation of Th cells into Th1 effectors that secrete IFNγ is crucial for activating macrophages to eliminate the intracellular parasites. IFNγ enhances the microbicidal activity of macrophages, helping to control the infection.
Choice A is incorrect because IL-4 is not required to induce the appropriate antibody response against Leishmania parasites.
Choice B is incorrect because Th2 effectors secreting IL-4 would not activate macrophages effectively against Leishmania, which is an intracellular pathogen.
Choice D is incorrect because in the case of Leishmania, a Th1-mediated response is most effective due to the need for macrophage activation by IFNγ.