ATI the Immune System Test Quizlet Related

Review ATI the Immune System Test Quizlet related questions and content

A protective response to Leishmania parasites is most likely to occur when:

  • A. Activated Th cells differentiate into Th1 effectors that secrete IL-4 required to induce secretion of appropriate antibody isotypes
  • B. Activated Th cells differentiate into Th2 effectors that secrete IL-4 required to activate macrophages
  • C. Activated Th cells differentiate into Th1 effectors that secrete IFNγ required to activate macrophages
  • D. Either a Th1- or a Th2-mediated response occurs
Correct Answer: C

Rationale: The correct answer is C because in response to Leishmania parasites, the activation of Th cells into Th1 effectors that secrete IFNγ is crucial for activating macrophages to eliminate the intracellular parasites. IFNγ enhances the microbicidal activity of macrophages, helping to control the infection.

Choice A is incorrect because IL-4 is not required to induce the appropriate antibody response against Leishmania parasites.

Choice B is incorrect because Th2 effectors secreting IL-4 would not activate macrophages effectively against Leishmania, which is an intracellular pathogen.

Choice D is incorrect because in the case of Leishmania, a Th1-mediated response is most effective due to the need for macrophage activation by IFNγ.