Nokea
Because of the pattern of cholesterol synthesis, reductase inhibitors are given:
- A. In the evening in a single daily dose
- B. Twice daily in the morning and the evening
- C. With each meal and at bedtime
- D. In the morning before eating
Correct Answer: A
Rationale: Cholesterol synthesis peaks at night, so evening dosing optimizes reductase inhibitor efficacy.
You may also like to solve these questions
Genetic testing for VCORC1 mutation to assess potential warfarin resistance is required prior to prescribing warfarin.
- A. TRUE
- B. FALSE
Correct Answer: B
Rationale: VCORC1 testing is recommended but not required before prescribing warfarin; it's optional to guide dosing.
B-Blockers are contra indicated in
- A. Hypertension
- B. Congestive cardiac failure
- C. Anxiety states
- D. Hyperthyroidis m
Correct Answer: B
Rationale: Beta-blockers worsen congestive heart failure.
Fasting for an extended period can:
- A. Increase drug absorption due to lack of competition between food and the drug
- B. Alter the pH of the gastrointestinal tract, affecting absorption
- C. Cause vasoconstriction, leading to decreased drug absorption
- D. Shrink the stomach, causing decreased surface area for drug absorption
Correct Answer: A
Rationale: Fasting increases absorption of some drugs by eliminating food-related delays in gastric emptying and competition for absorption.
A young adult is receiving a maintenance dose of aminophylline, 3 mg/kg PO q6h. The patient weighs 50 kg. How much should the patient receive in a 24-hour period?
- A. 200 mg
- B. 400 mg
- C. 600 mg
- D. 800 mg
Correct Answer: C
Rationale: Use the formula, amount of drug prescribed weight of the patient in kg 4 (q6h in a 24-hour period = 4). 3 50 = 150 mg to be given every 6 hours. To determine how much the patient will receive in a 24-hour period, divide 6 into 24 to equal 4 doses. 4 150 = 600 mg.
Sadie was prescribed betaxolol ophthalmic drops by her ophthalmologist to treat her glaucoma. Oral beta blockers should be avoided in patients who use ophthalmic beta blockers because:
- A. There may be an antagonistic reaction between the two
- B. The additive effects may include bradycardia
- C. They may potentiate each other and cause respiratory depression
- D. The additive effects may cause metabolic acidosis
Correct Answer: B
Rationale: Ophthalmic betaxolol can add to oral beta blockers, risking bradycardia; respiratory or acidosis are less likely.