Hematologic System Assessment Questions Related

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Hemolytic disease of the newborn caused by Rh blood group incompatibility requires maternal antibody to enter the fetal bloodstream. Therefore, the mediator of this disease is

  • A. IgE antibody
  • B. IgG antibody
  • C. IgM antibody
  • D. IgA antibody
Correct Answer: B

Rationale: The correct answer is B: IgG antibody. In hemolytic disease of the newborn, maternal IgG antibodies against fetal Rh-positive red blood cells can cross the placenta and attack the fetal RBCs, leading to hemolysis. IgE is primarily involved in allergic reactions, not hemolytic disease. IgM antibodies are too large to cross the placenta efficiently. IgA is not typically involved in hemolytic diseases. Therefore, IgG is the most likely mediator of hemolytic disease of the newborn in cases of Rh blood group incompatibility.