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Identify potential drug-drug interactions that may occur with tamoxifen
- A. Not provided in document
- B. Not provided in document
- C. Not provided in document
- D. Not provided in document
Correct Answer: D
Rationale: This question lacks options in the document, but based on the answer key (ANS: 4), it is assumed to correspond to the fourth choice if options were present. Tamoxifen has significant interactions with CYP2D6 inhibitors (e.g., SSRIs), which can reduce its efficacy.
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Which of the following sign/symptom would NOT be expected from organophosphate poisoning?
- A. Dry skin and mucous membranes
- B. Increased salivation
- C. Increased bowel sounds
- D. Urinary urgency
Correct Answer: A
Rationale: Organophosphates cause wet symptoms (salivation, etc.); dry skin is typical of anticholinergics.
The NP orders a thyroid panel for a patient on amiodarone. The patient tells the NP that he does not have thyroid disease and wants to know why the test is ordered. Which is a correct response?
- A. Amiodarone inhibits an enzyme that is important in making thyroid hormone and can cause hypothyroidism.
- B. Amiodarone damages the thyroid gland and can result in inflammation of that gland, causing hyperthyroidism.
- C. Amiodarone is a broad-spectrum drug with many adverse effects. Many different tests need to be done before it is given.
- D. Amiodarone can cause corneal deposits in up to 25% of patients.
Correct Answer: A
Rationale: Amiodarone inhibits thyroid hormone synthesis, risking hypothyroidism.
Which of the following drugs is used to accelerate pulmonary maturation in the fetus in women with premature labor?
- A. Aminoglutethimide
- B. Betamethasone
- C. Mifepristone
- D. Misoprostol
Correct Answer: B
Rationale: Betamethasone, a glucocorticoid, is administered to enhance fetal lung maturation by stimulating surfactant production in preterm labor.
True contraindications to diphtheria, tetanus, and acellular pertussis (DTaP or Tdap) vaccine include:
- A. Fever up to 104°F (40.5°C) after previous DTaP vaccine
- B. Family history of seizures after DTaP vaccine
- C. Adolescent pregnancy
- D. Anaphylactic reaction with a previous dose
Correct Answer: D
Rationale: Anaphylaxis is a true contraindication to DTaP/Tdap; fever , family history , or pregnancy are not.
A patient presents to the emergency department with a drug level of 50 units/mL. The half-life of this drug is 1 hour. With this drug, concentrations above 25 units/mL are considered toxic and no more drug is given. How long will it take for the blood level to reach the non-toxic range?
- A. 30 minutes
- B. 1 hour
- C. 2 hours
- D. 3 hours
Correct Answer: B
Rationale: Half-life is the time required for the serum concentration of a drug to decrease by 50%. After 1 hour, the serum concentration would be 25 units/mL (50/2) if the body can properly metabolize and excrete the drug. After 2 hours, the serum concentration would be 12.5 units/mL (25/2) and reach the nontoxic range. In 30 minutes the drug level would be 37.5 units/mL, whereas in 3 hours the drug level would be 6.25.