Nokea
Protease inhibitors interfere with
- A. Release of new viral particles from infected cells
- B. Processing of gp160
- C. Proviral stage
- D. Reverse transcription of viral RNA into DNA
Correct Answer: D
Rationale: Protease inhibitors interfere with the final step in HIV replication, which is the cleavage of the polyprotein into individual functional proteins. Inhibiting protease prevents the formation of mature infectious viral particles. This step occurs after reverse transcription of viral RNA into DNA, making choice D the correct answer. Choices A, B, and C are incorrect because protease inhibitors do not affect the release of new viral particles, processing of gp160, or the proviral stage of HIV replication.
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Which of the following is NOT a secondary lymphoid organ?
- A. Bone marrow
- B. Spleen
- C. Lymph nodes
- D. Mucosal immune system
Correct Answer: A
Rationale: The correct answer is A: Bone marrow. Secondary lymphoid organs are where immune responses are initiated. Bone marrow is a primary lymphoid organ where immune cells mature, not where immune responses are initiated like in secondary lymphoid organs. The spleen, lymph nodes, and mucosal immune system are all secondary lymphoid organs where immune responses occur.
A 28-year-old male Gulf War veteran tells the nurse he gets a headache, sore throat, shortness of breath, and nausea when his girlfriend wears perfume and when he was painting her apartment. He is afraid he has cancer. What does the nurse suspect may be the patient’s problem?
- A. He has posttraumatic stress disorder.
- B. He has multiple chemical sensitivities.
- C. He needs to wear a mask when he paints.
- D. He is looking for an excuse to break up with his girlfriend.
Correct Answer: B
Rationale: Multiple chemical sensitivities could explain the patient's symptoms triggered by exposure to various chemicals.
The nurse is reinforcing teaching to a person who has tested positive for HIV. Which test should the nurse explain is done to confirm the diagnosis of HIV?
- A. Western blot
- B. Rheumatoid factor
- C. Antinuclear antibodies
- D. Immunoglobulin assay
Correct Answer: A
Rationale: The correct answer is A: Western blot. This test is used to confirm the diagnosis of HIV by detecting specific antibodies produced in response to the virus. It is considered the gold standard for confirming HIV infection due to its high specificity and sensitivity. The other choices (B, C, D) are not used to diagnose HIV. Rheumatoid factor and antinuclear antibodies are tests for autoimmune conditions, while immunoglobulin assay measures levels of antibodies in the blood, not specific to HIV.
Which of the following statement is incorrect
- A. Antigens in tissues can reach regional LN via afferent lymphatic vessels
- B. Migrating dendritic cells that have collected antigens in tissues enter the draining LN via HEV
- C. During an infection fever and other inflammatory signals induce increased blood flow to draining LN and increased chances for lymphocytes to migrate from blood into LN
- D. The thoracic duct returns most of the circulating lymphocytes back to blood
Correct Answer: B
Rationale: The correct answer is B because migrating dendritic cells do not enter the draining lymph node (LN) via high endothelial venules (HEV); instead, they enter through afferent lymphatic vessels. HEVs are specialized post-capillary venules in LN where lymphocytes enter from the bloodstream. Dendritic cells, carrying antigens from tissues, travel via afferent lymphatic vessels to reach the LN where they present antigens to lymphocytes. Option A is correct as antigens in tissues reach LN via afferent lymphatic vessels. Option C is correct as infection-induced signals can increase blood flow to LN, facilitating lymphocyte migration. Option D is incorrect because the thoracic duct returns lymph back to the bloodstream, not specifically lymphocytes.
What is the name of a tumor from the embryonal mesoderm tissue of origin located in the anatomic site of the meninges that has malignant behavior?
- A. Meningitis
- B. Meningioma
- C. Meningocele
- D. Meningeal sarcoma
Correct Answer: D
Rationale: Meningeal sarcoma is a malignant tumor originating from the mesodermal tissue of the meninges.