Nokea
Which characteristics are seen with acute transplant rejection (select all that apply)?
- A. Treatment is supportive
- B. Only occurs with transplanted kidneys
- C. Organ must be removed when it occurs
- D. The recipient’s T cytotoxic lymphocytes attack the foreign organ
Correct Answer: D
Rationale: Acute transplant rejection involves the recipient's T cytotoxic lymphocytes attacking the transplanted organ, requiring immunosuppressive therapy.
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What is the main purpose of complement component C5a?
- A. Opsonization
- B. Cell lysis
- C. Recruitment and activation of immune cells
- D. Inhibition of inflammation
Correct Answer: C
Rationale: The correct answer is C: Recruitment and activation of immune cells. C5a is a potent chemoattractant that attracts immune cells to the site of infection or inflammation. It also activates these immune cells, leading to enhanced immune responses. Option A (Opsonization) and B (Cell lysis) are not the main functions of C5a. Option D (Inhibition of inflammation) is incorrect because C5a actually promotes inflammation by recruiting and activating immune cells.
Severe combined immunodeficiency (SCID) is a disease caused by:
- A. Infection with human immunodeficiency virus
- B. One of several inherited genetic mutations
- C. Deficiency of both innate and adaptive immune components
- D. Deficiency of hematopoietic stem cells
Correct Answer: B
Rationale: Step 1: SCID is a genetic disorder affecting the immune system.
Step 2: Inherited genetic mutations cause abnormalities in immune cells.
Step 3: These mutations lead to severe deficiencies in immune function.
Step 4: Choice B accurately reflects the genetic basis of SCID.
Summary: Choice A is incorrect because SCID is not caused by HIV. Choice C is incorrect as it oversimplifies the immune deficiencies in SCID. Choice D is incorrect because SCID primarily affects immune cells, not stem cells.
Where do T cells mature?
- A. Bone marrow
- B. Thymus
- C. Spleen
- D. Lymph nodes
Correct Answer: B
Rationale: The correct answer is B: Thymus. T cells mature in the thymus, where they undergo selection and maturation processes essential for their function in the immune system. The thymus provides a specialized environment for T cell development, including positive and negative selection to ensure self-tolerance and functional T cell repertoire.
A: Bone marrow is incorrect because it is the site of B cell maturation, not T cells.
C: Spleen is incorrect as it acts as a secondary lymphoid organ for immune response but not the site of T cell maturation.
D: Lymph nodes are incorrect as they are important for immune surveillance and activation but not the primary site for T cell maturation.
Which of the following statements about the 2009 H1N1 pandemic is NOT true
- A. Caused by a virus originated from 4 different strains
- B. Individuals over 60 were especially affected
- C. A level 6 pandemic phase was declared by WHO in June 2009
- D. 2009 H1N1 is considered moderately virulent in terms of severity of disease
Correct Answer: B
Rationale: The correct answer is B. Individuals over 60 were not especially affected by the 2009 H1N1 pandemic. This is because older individuals had some level of immunity due to previous exposure to similar strains. The other choices are incorrect because: A: The 2009 H1N1 virus originated from a combination of 2 different strains, not 4. C: WHO declared a level 6 pandemic phase in June 2009. D: The 2009 H1N1 virus was considered less virulent compared to other strains.
The nurse is caring for a patient with an infection. Which immunoglobulin should the nurse understand is produced first when an infection occurs?
- A. IgD
- B. IgE
- C. IgG
- D. IgM
Correct Answer: D
Rationale: Step-by-step rationale for why IgM is the correct answer:
1. IgM is the first immunoglobulin produced in response to an infection.
2. It is the largest immunoglobulin and is effective in agglutinating pathogens.
3. IgM activates the complement system to enhance immune response.
4. IgG is produced later in the immune response and provides long-term immunity.
5. IgD and IgE have specific roles but are not the initial immunoglobulins produced in response to infection.