Immune System Quizlet Related

Review Immune System Quizlet related questions and content

AIRE is expressed in

  • A. Bone marrow
  • B. Thymic cortical region
  • C. Thymic medullary region
  • D. LN cortex
Correct Answer: C

Rationale: The correct answer is C: Thymic medullary region. AIRE (Autoimmune Regulator) is expressed in the thymic medullary region. This region is crucial for central tolerance by deleting self-reactive T cells to prevent autoimmune reactions. AIRE regulates the expression of tissue-specific antigens in medullary thymic epithelial cells, leading to negative selection of autoreactive T cells. Choices A, B, and D are incorrect as AIRE is not primarily expressed in bone marrow, thymic cortical region, or LN cortex.