Nokea
All are explained on pharmacogenetic conditions except
- A. G6PD deficiency
- B. Warfarin insensitivity
- C. Adenosine deaminase deficiency
- D. Malignant hyperthermia
Correct Answer: C
Rationale: Adenosine deaminase deficiency is not typically pharmacogenetic; others are.
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A nurse is planning caring for a client who is has a new prescription for Torsemide. The nurse should plan to monitor for which of the following adverse reactions of this medications? (Select one that does not apply.)
- A. Respiratory acidosis
- B. Hypokalemia
- C. Hypotension
- D. Ototoxicity
Correct Answer: A
Rationale: Torsemide can cause hypokalemia , hypotension , ototoxicity , and dysrhythmias , typical loop diuretic effects.
A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the body may lead to:
- A. Decreased effectiveness of irinotecan in the treatment of cancer
- B. Increased adverse drug reactions, such as neutropenia
- C. Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38
- D. Increased concerns for irinotecan being carcinogenic
Correct Answer: B
Rationale: UGT1A1 mutations slow SN-38 inactivation, raising neutropenia risk , not affecting efficacy or activation .
All of following are examples of prodrugs except
- A. Levodopa
- B. Enlapril
- C. Omeprazole
- D. Indomethacin
Correct Answer: D
Rationale: Prodrugs (e.g., levodopa, enalapril, omeprazole) are inactive until metabolized. Indomethacin is active as administered.
Which of the following is synthetic mineralocorticoids:
- A. Testosterone
- B. Estradiol
- C. Fludrocortisone
- D. Hydrocortisone
Correct Answer: C
Rationale: Fludrocortisone is a synthetic mineralocorticoid used to mimic aldosterone's effects on sodium retention.
If an agonist can produce maximal effects and has high efficacy it's called:
- A. Partial agonist
- B. Antagonist
- C. Agonist-antagonist
- D. Full agonist
Correct Answer: D
Rationale: A full agonist achieves maximal receptor activation and effect.