Nokea
Which of the following drug used in the treatment of filariasis? *
- A. Diethyl carbamazine
- B. Albendazole
- C. Levamisole
- D. Piperazine
Correct Answer: A
Rationale: Diethyl carbamazine is the correct answer for the treatment of filariasis as it is the drug of choice due to its effectiveness in killing microfilariae and adult worms. Diethyl carbamazine directly targets the parasites responsible for filariasis, leading to their death and eventual elimination from the body. Albendazole, Levamisole, and Piperazine are not commonly used for filariasis treatment and are more commonly used for other parasitic infections. Albendazole is more commonly used for helminthic infections, Levamisole for roundworm infections, and Piperazine for pinworm infections.
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Which of the following drugs valuable in the treatment of edema and * metabolic alkalosis?
- A. Digoxin
- B. Spironalctone
- C. Dobutamine
- D. Acetazolamide
Correct Answer: D
Rationale: The correct answer is D: Acetazolamide. Acetazolamide is a diuretic that inhibits carbonic anhydrase enzyme, leading to increased excretion of bicarbonate ions, thus causing metabolic alkalosis correction and reducing edema. Digoxin (A) is used for heart failure, Spironolactone (B) is a potassium-sparing diuretic, and Dobutamine (C) is a beta-adrenergic agonist used for heart failure, none of which directly address metabolic alkalosis.
Which statement accurately describes glomerular filtration rate (GFR)?
- A. The primary function of GFR is to excrete nitrogenous waste products.
- B. Decreased permeability in the glomerulus causes loss of proteins into the urine.
- C. The GFR is primarily dependent on adequate blood flow and adequate hydrostatic pressure.
- D. The GFR is decreased when prostaglandins cause vasodilation and increased renal blood flow.
Correct Answer: C
Rationale: Step-by-step rationale:
1. Adequate blood flow is essential for GFR as it ensures efficient filtration of blood in the glomerulus.
2. Adequate hydrostatic pressure within the glomerulus is needed to push filtrate into the tubules.
3. If blood flow or hydrostatic pressure is inadequate, GFR will decrease.
4. Option A is incorrect as GFR primarily filters blood, not excretes waste products.
5. Option B is incorrect as increased permeability in the glomerulus leads to protein loss, not decreased.
6. Option D is incorrect as prostaglandins causing vasodilation would increase, not decrease, GFR.
Summary:
The correct answer is C because GFR is primarily dependent on adequate blood flow and hydrostatic pressure. Other choices are incorrect as they do not accurately describe the factors affecting GFR.
What does the dialysate for PD routinely contain?
- A. Calcium in a lower concentration than in the blood
- B. Sodium in a higher concentration than in the blood
- C. Dextrose in a higher concentration than in the blood
- D. Electrolytes in an equal concentration to that of the blood
Correct Answer: C
Rationale: Correct Answer: C - Dextrose in a higher concentration than in the blood
Rationale:
1. Dextrose in PD dialysate helps to create an osmotic gradient for fluid removal.
2. Higher dextrose concentration ensures effective ultrafiltration.
3. Dextrose is the main osmotic agent used in PD.
4. A higher concentration of dextrose in the dialysate aids in waste removal.
Summary:
A: Incorrect - Calcium concentration in dialysate is similar to blood to avoid imbalance.
B: Incorrect - Sodium concentration is lower in dialysate to prevent sodium loading.
D: Incorrect - Electrolyte concentration in dialysate is tailored to patient needs, not equal to blood.
Which of the following semisynthetic penicillins which has an extended spectrum of activity against many gram negative bacilli, is acid resistant but not penicillinase resistant?:
- A. Cloxacillin
- B. Amoxicillin
- C. Phenoxymethyl penicillin
- D. Piperacillin
Correct Answer: B
Rationale: The correct answer is B: Amoxicillin. This penicillin has an extended spectrum of activity against gram-negative bacilli, making it effective against a wider range of bacteria. It is acid-resistant, allowing it to be taken orally, but it is not penicillinase-resistant, meaning it can be easily degraded by beta-lactamase enzymes.
A: Cloxacillin is penicillinase-resistant but does not have an extended spectrum against gram-negative bacilli.
C: Phenoxymethyl penicillin is not acid-resistant and does not have an extended spectrum against gram-negative bacilli.
D: Piperacillin has an extended spectrum of activity but is not acid-resistant and is susceptible to penicillinase.
Due to its potential for severe hepatotoxicity, Nevirapine should NOT be initiated in:
- A. Women with CD4 cell counts >150 cells/mm3 or in men with CD4 cell count >400 cells/mm3
- B. Women with CD4 cell counts >250 cells/mm3 or in men with CD4 cell count >400 cells/mm3
- C. Women with CD4 cell counts >250 cells/mm3 or in men with CD4 cell count >500 cells/mm3
- D. Women with CD4 cell counts >250 cells/mm3 or in men with CD4 cell count >450 cells/mm3
Correct Answer: B
Rationale: The correct answer is B. Nevirapine has a higher risk of severe hepatotoxicity in patients with higher CD4 cell counts. Choice B specifies a lower threshold for CD4 cell counts in women compared to men, which aligns with the caution needed for initiating Nevirapine. Choices A, C, and D have higher CD4 cell count thresholds for both women and men, which would increase the risk of hepatotoxicity if Nevirapine is initiated in those patients. Therefore, Choice B is the most appropriate option to minimize the risk of hepatotoxicity when initiating Nevirapine.