Genitourinary System Diseases Related

Review Genitourinary System Diseases related questions and content

Which of the following new drug is indicated in managing SIADH, non – peptide and competitive antagonist of ADH’s water sparing effects in the collecting ducts of nephron?

  • A. Mannitol
  • B. Bumetanide
  • C. Spironolactone
  • D. Conivaptan
Correct Answer: D

Rationale: The correct answer is D: Conivaptan. Conivaptan is a non-peptide competitive antagonist of ADH, indicated for managing SIADH by blocking ADH's water-sparing effects in the collecting ducts. Mannitol (A) is an osmotic diuretic used for reducing intracranial pressure, not specifically for SIADH. Bumetanide (B) is a loop diuretic used for conditions like heart failure and edema. Spironolactone (C) is a potassium-sparing diuretic used for conditions like hypertension and heart failure, not specifically for SIADH.